The spine can be the source of a variety of pain presentations. Pain may localized to the neck or lower back, or it might radiate down an arm or a leg and cause weakness, tingling, or a burning sensation. The complex structure and biomechanics of the spine means that there are a number of anatomical structures that can cause pain. Spine-related pain can be due to an acute event such as a painful fall or sudden twisting, degenerative changes that occur as we age, or from infections and tumors. Below are some of the most common causes of spine-related pain.