i-FACTOR Bone Graft is based on the biological activity of the synthetically derived 15-amino acid peptide found naturally in Type I human collagen. This 15-amino acid peptide (P-15) is responsible for the attachment and proliferation of osteogenic cells. These cells have an affinity for and attach to the P-15 found in i-FACTOR Bone Graft in a similar way they would naturally with Type I collagen in bone.
i-FACTOR Bone Graft facilitates and expedites the ingrowth of bone by promoting the migration of mesenchymal stem cells and other progenitor cells from surrounding tissue.
The FIRST Peptide Enhanced Bone Graft approved by the FDA for Spine Surgery
Rely on Evidence
1cc 2.5cc 5cc
Level-1 Human Evidence
FDA PMA Study
Burden of Proof
The high affinity between cells and P-15 supports the physiological mechanism of action in which cells bind to the P-15 and “turn on” to perform their genetically programmed job of making bone.
The novel i-FACTOR Bone Graft “Attract, Attach, Activate” mechanism of action enhances the body’s natural bone healing process.