i-FACTOR Bone Graft is based on the biological activity of the synthetically derived 15-amino acid peptide found naturally in Type I human collagen. This 15-amino acid peptide (P-15) is responsible for the attachment and proliferation of osteogenic cells. These cells have an affinity for and attach to the P-15 found in i-FACTOR Bone Graft in a similar way they would naturally with Type I collagen in bone.

i-FACTOR Bone Graft facilitates and expedites the ingrowth of bone by promoting the migration of mesenchymal stem cells and other progenitor cells from surrounding tissue.


The FIRST Peptide Enhanced Bone Graft approved by the FDA for Spine Surgery

Rely on Evidence

Rely on Evidence

i-FACTOR Syringe

i-FACTOR Syringe

1cc  2.5cc  5cc

1cc 2.5cc 5cc

Level-1 Human Evidence

Level-1 Human Evidence



Product Details



Burden of Proof

Breakthrough Technology

i-FACTOR Brochure

The high affinity between cells and P-15 supports the physiological mechanism of action in which cells bind to the P-15 and “turn on” to perform their genetically programmed job of making bone.

The novel i-FACTOR Bone Graft “Attract, Attach, Activate” mechanism of action enhances the body’s natural bone healing process.

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